'How to change a single value in a NumPy array?

I want to change a single element of an array. For example, I have:

A = np.array([1,2,3,4],
             [5,6,7,8],
             [9,10,11,12],
             [13,14,15,16])

I want to relace A[2][1] = 10 with A[2][1] = 150. How can I do it?

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