SqlAlchemy equivalent of pyodbc connect string fails

Question

The following works:

import pyodbc
import sqlalchemy as sa
import pandas as pd 

cnxn = pyodbc.connect('Driver=ODBC Driver 17 for SQL Server;Server=MyServer;Database=MyDB;Trusted_Connection=yes;')
sql = ("SELECT * FROM MyTable") 
data_df = pd.read_sql(sql,cnxn)  

The following do not work:

params = urllib.parse.quote_plus('Driver={ODBC Driver 17 for SQL Server};Server=MyServer;Database=MyDB;Trusted_Connection=yes;')
engine = sa.create_engine('mssql+pyodbc:///?odbc_connect=%s' % (params))
orgnummer_df = pd.read_sql_table("MyTable", engine)

Error message: Exception has occurred: ValueError Table MyTable not found

So I assume there is something wrong with my engine, but I am unable to figure it out... Can someone please point me in the right direction? Thanks!