'how to convert comma separated string to comma seperated int in python

i'm trying to convert any timezone time to uk time. i'm getting the value error in the time_format variable.

from datetime import datetime
from pytz import timezone

newyork_tz = timezone('America/New_York')
london_tz = timezone('Europe/London')

it is in type string and when i'm trying to convert to int it is giving me this error

ValueError: invalid literal for int() with base 10: '2022, 02, 02, 21, 32, 25'

expecting out like below with type int

2022, 02, 02, 21, 28, 15

i'm new to python plz guide me with possible solution

python casting

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