'How do I access the other 3 ports on the Arduino Mega 2560?

I've been trying to send data from my MacBook to my Arduino. First the UNO. But I want to debug my program by printing the data on the serial monitor in the Arduino IDE. This didn't work with the Uno so I purchased the Mega 2560. I made an adapter by cutting off one end of a USB cable, crimping 4 pins onto it and hooking up the pins to tx1 18 & rx1 19 as described in several web explanations. With ground & 5v accordingly. On my laptop, I'm using python. this line:

arduino = serial.Serial(port='/dev/cu.usbmodem143401',
                        baudrate=115200, timeout=1)

didn't work with the UNO since this port was providing the IDE serial monitor - hence the purchase of the Mega.

So how do I designate the next port on the Mega?

If I use:

    (.venv) Serial_Port > python -m serial.tools.list_ports

I get:

/dev/cu.BLTH        
/dev/cu.Bluetooth-Incoming-Port
/dev/cu.BoseQC35II  
/dev/cu.usbmodem14201

the last port is the one in which the Adruino is using as the monitor. But nothing suggesting the tx1 18 & rx1 19 port shows up. Without the standard USB connection I get:

    (.venv) Serial_Port > python -m serial.tools.list_ports
/dev/cu.BLTH        
/dev/cu.Bluetooth-Incoming-Port
/dev/cu.BoseQC35II  
3 ports found

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'How do I access the other 3 ports on the Arduino Mega 2560?

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