Filtration of pandas dataframe python

Question

I need to extract some parameters from specific rows of CSV file into a new file Here is an explanation for what I'm trying to do

File1 = pd.read_csv('File1.csv', encoding='ISO-8859-1')  
Arr = File1['AAA'].unique(),File1['BBB'].unique(),File1['CCC'].unique() /// Array of integers 

Then I need to take the values inside the Array and extract the matched rows from specific columns from file2 which contains:

A more explanation

I need to extract the rows which matched these values from file2(I'm focusing on DDDD, EEEE columns) and export them in a new data frame file contain from these rows to minimize the size of the file.