column transformer on dataframe for one-hot encoding

Question

                                         3      4  \
0      macrolide-lincosamide-streptogramin   macB   
1      macrolide-lincosamide-streptogramin   macB   
2                                multidrug   cmeB   
3      macrolide-lincosamide-streptogramin   macA   
4                            pleuromutilin   TaeA   
...                                    ...    ...   
17277                         trimethoprim  dfrB7   
17278                          sulfonamide   folp   
17279                             rifampin   rpoB   
17280                             rifampin   rpoB   
17281                            elfamycin  tufab   

                                   5  6  \
0       antibiotic target protection  0   
1                  antibiotic efflux  0   
2                  antibiotic efflux  0   
3                  antibiotic efflux  0   
4                  antibiotic efflux  0   
...                              ... ..   
17277  antibiotic target replacement  0   
17278   antibiotic target alteration  0   
17279   antibiotic target alteration  0   
17280   antibiotic target alteration  0   
17281   antibiotic target alteration  0   

I have dataframe which I would like to one-hot encode. however, in order to do it, I read that I column transformer is needed, so that the data type matches the requirement for one-hot encoding. Since the column number may be added in the future as the datasets expand, I would like to create command line that has the capacity to do so instead of specifying the number of the column that I want to transform. Is there anyone who knows how to do so?

Thank you for your help in advance!