Why is a wxWidgets hello world GUI application flagged as a virus by various AVs?

Question

I made a GUI application in wxWidgets and kept receiving anti virus alerts by various users. I spent a great amount of time commenting out code and re-uploading the EXE to VirusTotal. It turns out, none of this was my code. Using the wxWidgets framework alone will cause plenty of detections. I tried again by compiling a simple hello world application and sure enough, this is the result:

Full source code:

// wxWidgets "Hello world" Program
// For compilers that support precompilation, includes "wx/wx.h".
#include <wx/wxprec.h>
#ifndef WX_PRECOMP
#include <wx/wx.h>
#endif

// Required for static linking
#pragma comment(lib, "comctl32")
#pragma comment(lib, "Rpcrt4")

class MyApp : public wxApp
{
public:
    virtual bool OnInit();
};
class MyFrame : public wxFrame
{
public:
    MyFrame(const wxString& title, const wxPoint& pos, const wxSize& size);
private:
    void OnHello(wxCommandEvent& event);
    void OnExit(wxCommandEvent& event);
    void OnAbout(wxCommandEvent& event);
    wxDECLARE_EVENT_TABLE();
};
enum
{
    ID_Hello = 1
};
wxBEGIN_EVENT_TABLE(MyFrame, wxFrame)
EVT_MENU(ID_Hello, MyFrame::OnHello)
EVT_MENU(wxID_EXIT, MyFrame::OnExit)
EVT_MENU(wxID_ABOUT, MyFrame::OnAbout)
wxEND_EVENT_TABLE()
wxIMPLEMENT_APP(MyApp);
bool MyApp::OnInit()
{
    MyFrame* frame = new MyFrame("Hello World", wxPoint(50, 50), wxSize(450, 340));
    frame->Show(true);
    return true;
}
MyFrame::MyFrame(const wxString& title, const wxPoint& pos, const wxSize& size)
    : wxFrame(NULL, wxID_ANY, title, pos, size)
{
    wxMenu* menuFile = new wxMenu;
    menuFile->Append(ID_Hello, "&Hello...\tCtrl-H",
        "Help string shown in status bar for this menu item");
    menuFile->AppendSeparator();
    menuFile->Append(wxID_EXIT);
    wxMenu* menuHelp = new wxMenu;
    menuHelp->Append(wxID_ABOUT);
    wxMenuBar* menuBar = new wxMenuBar;
    menuBar->Append(menuFile, "&File");
    menuBar->Append(menuHelp, "&Help");
    SetMenuBar(menuBar);
    CreateStatusBar();
    SetStatusText("Welcome to wxWidgets!");
}
void MyFrame::OnExit(wxCommandEvent& event)
{
    Close(true);
}
void MyFrame::OnAbout(wxCommandEvent& event)
{
    wxMessageBox("This is a wxWidgets' Hello world sample",
        "About Hello World", wxOK | wxICON_INFORMATION);
}
void MyFrame::OnHello(wxCommandEvent& event)
{
    wxLogMessage("Hello world from wxWidgets!");
}

How can these be fixed without contacting each AV vendor? Clearly, the code is not malicious and wxWidgets is a popular cross-platform GUI framework which shouldn't cause any AV detections on its own. The static EXE however is quite big and pulls in a lot of Windows API functions so it's hard to even pinpoint anything.