Npx-Create Command vs Custom React Boilerplate When Think About webpack?

Question

I am a new at React stuff and come here from Angular. So for learning react I am watching course which teacher is Andrew Mead . He building a react app from zero to hero , I understand and appreciated but I am confused about webpack subject. He build separate webpack config file and keeps build on app but when it comes to use npx-react command , a boilerplate created and there is no such thing separete webpack config file. But of course I am aware that any dependencies would comes with webpack dependency anyway. My question is , is it good thing use npx-react command for beginner to the advance level app ? In future , Will I have to use seperate webpack config file ? What is the best practice in React World ?

Best Regards,