How to remove special characters from columns D and F?

Question

I have data in column D and F which might have special characters (, . / + &() etc.).
I want to remove the special characters if any and trim clean the columns.

Sub Splchrdel()

Dim ws As Worksheet
Dim Rng As Range

Set ws = ActiveWorkbook.Worksheets("Final Exclusion")

Set Rng = ws.Range("D2:D", "F2:F")
    
With ws

    Rng.Replace What:=(("&", ",", ".", "/", "-", "+", "#", "!", "%", "(", ")", "*", _
      "'", "", "$")) Replacement:="", LookAt:=xlPart, SearchOrder _
      :=xlByRows, MatchCase:=False, SearchFormat:=False, ReplaceFormat:=False
    
    Rng("D2:D:", "F2:F").Trim.Clean

End Sub

Answer 1

Please, test the next way. Replace cannot receive multiple strings as What parameter. So, the strings must be placed in an array and then replace each array element. Another issue: "*" must be escaped, if you want to replace only this character. Otherwise, everything will be replaced with a null string:

Sub Splchrdel()
 Dim ws As Worksheet, Rng As Range, lastR As Long, arrWhat, El

    Set ws = ActiveWorkbook.Worksheets("Final Exclusion")
    lastR = ws.Range("D" & ws.Rows.count).End(xlUp).row 'if F:F has different number of rows, another lastR should be calculated
    Set Rng = ws.Range("D2:D" & lastR & "," & "F2:F" & lastR) 'range only for D:D and F:F columns
   
    arrWhat = Array("&", ",", ".", "/", "-", "+", "#", "!", "%", "(", ")", "~*", "'", "", "$")
    For Each El In arrWhat
        Rng.Replace What:=El, replacement:="", LookAt:=xlPart, _
                   SearchOrder:=xlByRows, MatchCase:=False, SearchFormat:=False, _
                    ReplaceFormat:=False, FormulaVersion:=xlReplaceFormula2
    Next El
    'Since `Clean` does not work on a range, an iteration is needed:
    Dim cel As Range
    For Each cel In Rng.cells
        cel.Value = WorksheetFunction.Clean(Trim(cel.Value))
    Next
End Sub