Create MySQL user using PDO/Eloquent with bindValue

Question

I am working on an application that needs an ability to create MySQL users and schemas. But I am having issues with running the CREATE USER statement

I would expect this statement to work but it does not:

DB::statement('CREATE USER :user@`%` IDENTIFIED WITH mysql_native_password BY :password', [
    'user' => $this->username,
    'password' => $this->password,
]);

Under the hood Laravel sends the entire statement to PDO without doing any processing,
so this is pretty much the same as if I would call:

$statement = $pdo->prepare('CREATE USER :user@`%` IDENTIFIED WITH mysql_native_password BY :password');
$statement->bindValue('user', $this->username, PDO::PARAM_STR);
$statement->bindValue('password', $this->password, PDO::PARAM_STR);
$statement->execute();

I did a bunch of googling and all solutions I found used string concatenation, but I would prefer to use parameter binding.
I also tried many different ways of running this statement but none worked:

CREATE USER :user@% IDENTIFIED WITH mysql_native_password BY :password
CREATE USER :user@'%' IDENTIFIED WITH mysql_native_password BY :password
CREATE USER ':user'@'%' IDENTIFIED WITH mysql_native_password BY ':password'
CREATE USER `:user`@`%` IDENTIFIED WITH mysql_native_password BY `:password`
CREATE USER :user@'%'
CREATE USER ':user'@'%'
CREATE USER `:user`@'%'
CREATE USER :user
CREATE USER ':user'
CREATE USER `:user`
CREATE USER :user  -- with ['user' => $this->username . '@`%`'

What am I missing? Is it not possible to run CREATE USER with bindValues?

edit: To add context they are all failing at prepare() except for the ones where the parameter is in a comment, since those dont consider it a parameter, just a literal.